Proliferant Solutions Used In Prolotherapy You Should Know

Proliferant Solutions Used In Prolotherapy You Should Know. Prolotherapy is a type of treatment for ligament and joint injury using injection. This method can strengthen the weak tendon and ligament so the body movement getting stronger and healthier. The injected solution used in prolotherapy called Proliferants. The function of it is to cause a local irritation which indicates the inflammation. The next process will trigger the tissue to heal which resulting in establishing injured tendon, joint, and ligament. The purpose of prolotherapy is also to reduce pain caused by the broken tissue or injure the ligament. After injection by Proliferants, the process of healing to get movement stability is about six to seven weeks after the first treatment.

Based on the mechanism of Prolotherapy, Proliferant solutions are varied. Even though there are some types of proliferating, the purpose is to cause localized inflammation. Later, the inflammation will stimulate an influx of inflammatory cells. Most of theĀ  Proliferant used for prolotherapy are divide into three major classes, the chemotactic irritants, and the osmotic. The solution of the Proliferant can also combine with Local anesthetic such as lignocaine to reduce the pain in the area of injection. Here are the details of those proliferations.

Skin Irritation

Proliferant Solutions Used In Prolotherapy You Should Know
Irritation in the Arm

The most common use of proliferant solutions is that these chemical irritants react by directly damaging cells. So the way it works is by wrapping antigenic cells. Such irritants are phenol-glycerin-glucose, tannic acid, guaiacol, and phenols, other types of irritants are particulates, such as pumice flour, The way particulates work is different from the way phenol reacts. The workings of particulates are by stimulating cellular trauma. The first is injection into the injured part of the body so that it can attract macrophages. This condition causes swallowing of tissues and secretes polypeptide growth factors. In some cases, it is actually rare because some injection areas can attract granulocytes and macrophages. After a while, early inflammation will occur, meaning that the healing process will begin immediately.

The Chemotaxis Movement

Proliferant Solutions Used In Prolotherapy You Should Know

Chemotaxis has a different way of reacting with the injured tissue. This substance will be direct biosynthetic precursors to the inflammation. The reaction will take place with the mediator such as leukotrienes, prostaglandins, and thromboxanes. Sodium morrhuate is an example of Chemotaxis. Sodium morrhuate can attract inflammatory cells because it contains the biosynthetic precursor. It has become chemotactic agents. This compound is derived from cod liver oil in the shape of sodium salt of fatty acid.


Proliferant Solutions Used In Prolotherapy You Should Know
Osmotic Pressure

If proliferate is divided into classes, then osmotic will be the third class of proliferating. This is a concentrated solution contains zinc sulfate, glucose, and glycerin. After injected to the injured ligament or joint, it will hydrate the cell in the injection area. This condition can cause an osmotic shock. This is needed to lead the cell releasing pro-inflammatory substances. Cellular fragment such as membrane and protein is emancipated by the cell at the injection area. The state trigger granulocytes and macrophages to react, so the local tissue around the injected area instigate an influx of inflammatory cells. All of the processes lead to wound healing.